Harpoon Therapeutics Presents Preclinical Data for HPN328, a DLL3-targeting T Cell Engager, at AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
HPN328, a TriTAC®, Exhibits the Potency, Tolerability, and Pharmacokinetics to Support Initiation of Clinical Development in 2020
“These encouraging data demonstrate that HPN328 can simultaneously engage DLL3, on a small cell lung cancer cell, and CD3, on a T cell, resulting in T cell activation and eventual lysis of the tumor,” said
Data presented in the poster showed that HPN328 directs T cells to kill DLL3 expressing cells in vitro and induces the elimination of tumors in models of small cell lung cancer. In cynomolgus monkeys, HPN328 has a terminal serum half-life of 68-79 hours and TriTACs, including HPN328, exhibit extended in vivo stability. Samples that were collected after more than one week in circulation maintained their full T cell engaging activity as demonstrated in ex-vivo assays support the potential for at least once weekly dosing. HPN328 was well tolerated in cynomolgus monkeys at 1 and 10 mg/kg. Initiation of a first in human Phase 1 clinical trial is planned for 2020.
About HPN328
HPN328 is Harpoon’s fourth Tri-specific T cell Activating Construct (TriTAC®) candidate in development. HPN328 targets DLL3, a protein highly expressed in a majority of SCLC tumors with limited expression in normal tissues. This selective expression makes DLL3 an attractive drug target for T cell engagers. Harpoon is currently conducting IND-enabling studies and expects to initiate a Phase 1 clinical trial of HPN328 in 2020.
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Source: Harpoon Therapeutics