Harpoon Therapeutics Presents Preclinical Data for HPN328, a DLL3-targeting T Cell Engager, at AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
HPN328, a TriTAC®, Exhibits the Potency, Tolerability, and Pharmacokinetics to Support Initiation of Clinical Development in 2020
“These encouraging data demonstrate that HPN328 can simultaneously engage DLL3, on a small cell lung cancer cell, and CD3, on a T cell, resulting in T cell activation and eventual lysis of the tumor,” said
Data presented in the poster showed that HPN328 directs T cells to kill DLL3 expressing cells in vitro and induces the elimination of tumors in models of small cell lung cancer. In cynomolgus monkeys, HPN328 has a terminal serum half-life of 68-79 hours and TriTACs, including HPN328, exhibit extended in vivo stability. Samples that were collected after more than one week in circulation maintained their full T cell engaging activity as demonstrated in ex-vivo assays support the potential for at least once weekly dosing. HPN328 was well tolerated in cynomolgus monkeys at 1 and 10 mg/kg. Initiation of a first in human Phase 1 clinical trial is planned for 2020.
HPN328 is Harpoon’s fourth Tri-specific T cell Activating Construct (TriTAC®) candidate in development. HPN328 targets DLL3, a protein highly expressed in a majority of SCLC tumors with limited expression in normal tissues. This selective expression makes DLL3 an attractive drug target for T cell engagers. Harpoon is currently conducting IND-enabling studies and expects to initiate a Phase 1 clinical trial of HPN328 in 2020.
Forward Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as “may,” “will,” “expect,” “plan,” “anticipate,” “target,” “estimate,” “intend” and similar expressions (as well as other words or expressions referencing future events, conditions or circumstances) are intended to identify forward-looking statements. These forward-looking statements are based on Harpoon Therapeutics’ expectations and assumptions as of the date of this press release. Each of these forward-looking statements involves risks and uncertainties that could cause Harpoon Therapeutics’ clinical development programs, future results or performance to differ significantly from those expressed or implied by the forward-looking statements. Forward-looking statements contained in this press release include, but are not limited to, statements about the timing of IND submissions, the progress, timing, scope and anticipated results of clinical trials, the timing of the presentation of data, the association of data with potential treatment outcomes, the development and advancement of product candidates, and the timing of development milestones for product candidates. Many factors may cause differences between current expectations and actual results, including unexpected safety or efficacy data observed during clinical studies, clinical trial site activation or enrollment rates that are lower than expected, changes in expected or existing competition, changes in the regulatory environment, the uncertainties and timing of the regulatory approval process, and unexpected litigation or other disputes. Other factors that may cause Harpoon Therapeutics’ actual results to differ from those expressed or implied in the forward-looking statements in this press release are discussed in Harpoon Therapeutics’ filings with the
Chief Financial Officer
Source: Harpoon Therapeutics