131 Oyster Point Blvd, Suite 300

South San Francisco, CA 94080

April 21, 2020


U.S. Securities and Exchange Commission

Division of Corporation Finance

Office of Life Sciences

100 F Street, N.E.

Washington, D.C. 20549

Attn: Irene Paik



Harpoon Therapeutics, Inc.


Registration Statement on Form S-3


Filed March 13, 2020


File No. 333-237175



Acceleration Request

  Requested Date:

April 23, 2020

  Requested Time:

4:00 P.M. Eastern Time

Ladies and Gentlemen:

In accordance with Rule 461 under the Securities Act of 1933, as amended, the undersigned registrant (the “Registrant”) hereby requests that the Securities and Exchange Commission take appropriate action to cause the above-referenced Registration Statement on Form S-3 (File No. 333-237175) (the “Registration Statement”) to become effective on April 23, 2020, at 4:00 p.m. Eastern Time, or as soon thereafter as is practicable, or at such later time as the Registrant may orally request via telephone call to the staff of the Division of Corporation Finance. The Registrant hereby authorizes each of Laura Berezin, Robert Phillips and Jonie Kondracki of Cooley LLP, counsel to the Registrant, to make such request on its behalf.

Once the Registration Statement has been declared effective, please orally confirm that event with Laura Berezin of Cooley LLP at (650) 843-5128, Robert Phillips of Cooley LLP at (415) 693-2020 or Jonie Kondracki of Cooley LLP at (415) 693-2174.

[Signature page follows]

Very truly yours,
Harpoon Therapeutics, Inc.
By:   /s/ Georgia Erbez
  Georgia Erbez
  Chief Financial Officer



Gerald McMahon, Harpoon Therapeutics, Inc.


Laura Berezin, Cooley LLP


Robert Phillips, Cooley LLP


Jonie Kondracki, Cooley LLP